Novel strategies for the early identification provention and treatment of the microvascular complications of diabetes [ 2002 - 2006 ]

Research Grant

Researchers: Richard Gilbert (Principal investigator) ,  A/Pr Silviu Itescu ,  Dr Christopher Wraight ,  Dr Mark Waltham ,  Prof Carol Pollock
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Brief description Despite recent advances, approximately one third of subjects with type 1 diabetes develop kidney disease and similar proportion develop vision-threatening eye disease. Indeed, in many instances eye and kidney disease occur in the same individual. The central aim of this proposed Special Program is the exploration of mechanisms that lead to the development and progression of these devastating complications of type 1 diabetes with a particular focus on novel strategies, directly applicable to man, for their prevention and treatment. Participants in Special Program include both established diabetes researchers and investigators from other areas of academia (blood vessel biology and applied genetics). Strong interrelationships between the various investigators and their departments already exist and will be further consolidated with continued collaboration, sharing a combination of models, novel interventions and complex genetic techniques that would not be possible outside of a large collaborative framework. In addition to academic collaboration, interactions with industry-based drug discovery programs is also an important component in developing new treatment strategies for diabetic kidney and eye disease. The Special Program will thus consist of a range of studies of direct relevance to diabetic kidney and diabetic eye disease in humans. It is expected that these studies will lead to new strategies for the prevention, treatment and even the reversal of long term complications of diabetes.

Funding Amount $AUD 4,715,000.00

Funding Scheme NHMRC Strategic Awards

Notes Diabetes Collaborative Research Grants