Novel perspectives on the function of AB5 toxin B subunits [ 2015 - ]

Research Grant

Researchers: Prof Adrienne Paton (Principal investigator) ,  Dr Travis Beddoe

Brief description AB5 toxins are important virulence factors of pathogenic bacteria. They comprise pentameric B subunits that bind to target cell surfaces and catalytic A subunits that damage host cell functions. This proposal examines a new paradigm wherein the B subunits are significant contributors to cell damage. We will characterize the cytopathic properties of diverse B subunits, particularly those of emerging toxins. This will provide novel insights into pathogenesis and inform development of therapeutics.

Funding Amount $1,002,230.00

Funding Scheme Project Grants

Notes Standard Project Grant