[Cite as http://purl.org/au-research/grants/nhmrc/545838]
Prof David Jans
Brief description The P-protein from rabies virus (RV) has distinct sequences that enable it to exploit the cellular skeleton (cytoskeleton) to localise efficiently in the host cell nucleus to exert pathogenic effects, or to perturb the cytoskeleton and thereby impair the host cell anti-viral response and immune response generally. We aim to characterise these properties in detail, demonstrate their importance to RV pathogenicity, and test the utility of the P-protein sequences in drug delivery.
Funding Amount $AUD 529,632.69
Funding Scheme NHMRC Project Grants
Standard Project Grant