Novel microtubule association sequences from rabies virus; subversion of antiviral responses and use in drug delivery [ 2009 - 2011 ]

Also known as: Microtubule-modulated subcellular trafficking and medical relevance

Research Grant

[Cite as]

Researchers: Prof David Jans (Principal investigator)

Brief description The P-protein from rabies virus (RV) has distinct sequences that enable it to exploit the cellular skeleton (cytoskeleton) to localise efficiently in the host cell nucleus to exert pathogenic effects, or to perturb the cytoskeleton and thereby impair the host cell anti-viral response and immune response generally. We aim to characterise these properties in detail, demonstrate their importance to RV pathogenicity, and test the utility of the P-protein sequences in drug delivery.

Funding Amount $AUD 529,632.69

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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