A Novel Metabolic Role for UDP Glycosyltransferase 8 (UGT8) [ 2015 - 2017 ]

Research Grant

Researchers: Dr Robyn Meech (Principal investigator) ,  Dr Michael Downes ,  E/Pr Peter Mackenzie ,  Prof Ross Mckinnon

Brief description The UDP glycosyltransferases (UGTs) are a family of enzymes that remove drugs and toxins from the human body as well as control levels of naturally produced molecules such as bile acids and hormones. We found that a new member of this family called UGT8 processes bile acids in the kidney and intestine and can affect how bile acids act to regulate metabolism. Our studies uncover new roles for bile acids in liver, kidney and gut health and in metabolic disorders such as diabetes and obesity.

Funding Amount $AUD 419,144.89

Funding Scheme Project Grants

Notes Standard Project Grant