grant

A novel marker of distressed neurons in the hypoxic brain: Regulation, function and potential clinical utility. [ 2009 - 2011 ]

Also known as: Investigating a protein that allows identification of distressed nerve cells in the brain

Funded by National Health and Medical Research Council
Managed by The University of Queensland
Managed by University of Queensland
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/569666]

Researchers: Prof David Pow (Principal investigator) ,  Prof Paul Colditz ,  Prof Philip Poronnik

Brief description The brain is easily damaged by lack of oxygen (hypoxia). We have recently identified a novel protein called GLAST1b which is expressed in distressed neurons. This protein is a glutamate transporter. Glutamate is implicated as a toxic agent hypoxia. This study will investigate what regulates the expression of GLAST1b, what the consequences of expression are, and whether this marker can be developed as a diagnostic tool for identifying the presence of, and distribution of brain damage.

Funding Amount $AUD 526,878.44

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Biomedical and Clinical Sciences | Medical Microbiology | Medical Microbiology Not Elsewhere Classified | NMDA | amino acid transport | brain ischaemia and traumatic injury | hypoxia-ischaemia-reperfusion injury to the brain | hypoxic-ischaemic encephalopathy | neonatal | neonatal brain injury | neonatal seizures | neuronal injury | stroke-cerebral ischaemia |
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