Novel Ligand-Specific Interactions Enable Mineralocorticoid Receptor Modulation [ 2018 - ]

Research Grant

Researchers: Prof Peter Fuller (Principal investigator) ,  A/Pr Timothy Cole ,  Dr Jun Yang ,  Dr Morag Young

Brief description The steroid hormone aldosterone controls salt balance and hence, blood pressure. It also has been shown to have a significant role in cardiac failure. Although drugs that block the aldosterone receptor are beneficial in the treatment of heart failure, they are limited by potassium retention in the kidney. In order to develop tissue-specific blockers of the aldosterone receptor, it is necessary to identify mechanisms by which the receptor can be activated and/or blocked in these tissues.

Funding Amount $835,005.00

Funding Scheme Project Grants

Notes Standard Project Grant