Novel HIV-1 glycoprotein vaccines with enhanced presentation of broad neutralization epitopes [ 2017 - ]

Research Grant

Researchers: Dr Pantelis Poumbourios (Principal investigator) ,  A/Pr Heidi Drummer ,  Dr Robert Center

Brief description A prophylactic vaccine represents the best strategy for blocking HIV-1 transmission but one is not yet available. Current antiviral vaccines rely on neutralizing antibodies (NAbs) that block infection, however, current HIV-1 vaccine formulations do not induce broadly reactive NAbs (bNAbs). We have discovered a novel HIV-1 glycoprotein vaccination candidate with enhanced presentation of bNAb epitopes. We propose to determine if this vaccine induces effective bNAbs in experimental animals.

Funding Amount $743,682.00

Funding Scheme Project Grants

Notes Standard Project Grant