A novel Hepatitis B virus genotype in Indigenous Australians: impact on vaccine efficacy and clinical outcomes [ 2014 - 2017 ]

Research Grant

Researchers: A/Pr Steven Tong (Principal investigator) ,  A/Pr Joshua Davis ,  A/Pr Nicholas Wood ,  Dr Margaret Littlejohn ,  Dr Nadia Warner
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Brief description We have recently identified a novel Hepatitis B virus (HBV) genotype (C4) circulating in Northern Territory (NT) Indigenous communities. Concurrently, epidemiological studies suggest that the HBV vaccine may not be working well and that there are high rates of liver cancer due to HBV in these communities. Our project will determine if HBV/C4 is linked to poor vaccine responses and accelerated liver disease, with implications for HBV vaccine strategy and clinical management of HBV/C4 infections.

Funding Amount $AUD 1,100,960.14

Funding Scheme Project Grants

Notes Standard Project Grant