A novel cytoskeletal structure in muscle is associated with muscular dystrophy [ 2005 - 2007 ]

Research Grant

Researchers: Prof Peter Gunning (Principal investigator) ,  Dr Anthony Kee ,  Prof Edna Hardeman

Brief description A NEW PROTEIN NETWORK IN MUSCLE IS ASSOCIATED WITH MUSCLE DISEASE An intricate protein network connects the contracting mechanism of a muscle to the surrounding cell membrane. Disruption of this connection is one of the known causes of muscular dystrophy. For many patients however the cause of the disease is unknown. We have identified a new region within this protein network that is also associated with muscle disease in mice. A number of proteins that are involved in transmitting chemical messages from one part of the muscle cell to another are found at this same location. It is possible that disruption of these messages may lead to muscle disease. This project aims to establish the nature of the relationship between the proteins found in this newly identified region of the protein network and muscle diseases such as muscular dystrophy, in both animal models and in humans. We expect that this project may identify new markers for identifying the cause of muscle diseases in some patients and lead to better hopes for an eventual cure.

Funding Amount $AUD 371,250.00

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant