Novel cell therapy for Hirschsprung Disease: from patient iPS cells to large animal trials [ 2017 - ]

Research Grant

Researchers: Dr Donald Newgreen (Principal investigator) ,  A/Pr Sebastian King ,  Prof Greg Qiao ,  Prof John Furness ,  Prof John Hutson

Brief description In Hirschsprung disease the lower bowel has no nerve cells. It does not function so it is surgically removed but quality of life is poor. A new idea is to replace the missing cells with new ones. Human infants are very large so we will use new stem cell technologies to create large numbers of cells. We will use polymer chemistry to devise a method of getting the cells into such a large organ as the bowel, and trial these on a model, the piglet, which closely resembles in size the human baby.

Funding Amount $1,011,764.00

Funding Scheme Project Grants

Notes Standard Project Grant