A novel cardiac inotropic mechanism that provides functional benefit [ 2009 - 2011 ]

Research Grant

Researchers: A/Pr Elizabeth Woodcock (Principal investigator) ,  Dr Siiri Iismaa

Brief description Patients with heart failure are often treated with an inotropic agent to increase the force of the heart's contraction and thus improve quality of life for these patients. Most inotropic agents have deleterious effects that limit their usefullness. Mice that have increased alpha1-A receptor expression in their hearts have heightened contactility that is not associated with hypertrophy or arrhythmias. We will use microarray, and si-RNA delivery and signalling studies to identify the mechanism.

Funding Amount $AUD 413,936.19

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant