Novel artemisinin-based combination therapies for children exposed to high transmission of multiple Plasmodium species [ 2010 - 2014 ]

Research Grant

Researchers: Prof Timothy Davis (Principal investigator) ,  A/Pr Harin Karunajeewa ,  Prof Ivo Mueller ,  Prof Kevin Batty ,  Prof Peter Siba
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Brief description We recently found that the WHO-recommended combination antimalarial therapy artemether-lumefantrine and the candidate regimen dihydroartemisinin-piperaquine were not fully effective for both falciparum and vivax malaria in young PNG children, a group at risk of complications and death. We plan to study two new combinations (artesunate-pyronaridine and artemisinin-naphthoquine) and hypothesise that at least one will prove superior and be used as first-line treatment in PNG and similar countries.

Funding Amount $AUD 1,378,408.08

Funding Scheme Project Grants

Notes Standard Project Grant