Noradrenaline transporter dysfunction in neural circulatory disorders: clinical, molecular and therapeutic implications [ 2008 - 2010 ]

Research Grant

Researchers: Prof Markus Schlaich (Principal investigator) ,  A/Pr Elisabeth Lambert ,  Prof Gavin Lambert

Brief description We will investigate the clinical relevance of noradrenaline transporter (NET) dysfunction and its molecular and genetic regulation in (1) essential hypertension, (2) postural tachycardia syndrome where the heart rate increases abnormally when the patient assumes an upright position and (3) syncope where subjects experience recurrent blackouts. In a therapeutic approach, we will explore whether NET inhibition can reduce the number of episodes and alleviate the symptoms associated with syncope.

Funding Amount $AUD 510,870.70

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant