A non-cytotoxic approach to reduce ocular fibrosis following surgery in glaucoma [ 2016 - 2018 ]

Research Grant

Researchers: Dr Hitesh Peshavariya (Principal investigator) ,  Prof Jonathan Crowston (Principal investigator) ,  Prof Gregory Dusting

Brief description Glaucoma surgery often leads to scar formation and blindness. We have identified a novel protein (NADPH oxidase 4; Nox4) which promotes scar formation in the eye. Lack of Nox4 in a mouse models reduces scar formation. We have demonstrated that a ‘repurposed’ drug which is currently used to treat lung diseases can also block Nox4 in the eye. We aim to determine whether this drug can be used as a novel therapy for vision loss after glaucoma surgery.

Funding Amount $AUD 603,710.95

Funding Scheme Project Grants

Notes Standard Project Grant