grant

Non-coding RNA regulation of virulence in enterohaemorrhagic E. coli [ 2014 - 2018 ]

Also known as: RNA based regulation in pathogenic bacteria

Funded by National Health and Medical Research Council
Managed by University of New South Wales
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1067241]

Brief description Shiga toxins cause potentially fatal haemolytic uremic syndrome (HUS) and are transferred between bacterial pathogens by bacteriophage (bacterial viruses). We have recently found that the Shiga toxin encoding bacteriophage encodes an unusually large number of non-coding RNAs (RNA regulators of gene expression). This Project aims to understand how these RNA regulators benefit the Shiga toxin bacteriophage and use this knowledge to develop interventions that will prevent expression of the toxin.

Funding Amount $AUD 389,313.31

Funding Scheme Project Grants

Notes New Investigator Grant

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Subjects
Medical and Health Sciences | Medical Microbiology | Medical Bacteriology | RNA | RNA binding proteins | bacterial evolution | bacterial pathogenicity | bacterial virulence factors | gene regulation | gene transcription | molecular genetics | molecular microbiology | sequencing |
Identifiers
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ACN 633 798 857