NK cells as the missing link between anti-cancer chemotherapy and CD8 T cell responses [ 2008 - 2011 ]

Research Grant

Researchers: Prof Richard Lake (Principal investigator) ,  A/Pr Anthony Scalzo ,  Dr Robbert Van Der Most ,  Prof Anna Nowak ,  Prof Bruce Robinson

Brief description Cytotoxic chemotherapy is the standard of care for most tumors but it rarely cures. The immune system has the capacity to destroy malignant cells but tumors usually evade immune destruction. Combination of chemo- immunotherapy may change this. DNA damage in tumor cells, caused by chemotherapy, induces expression of a set of molecules that activate Natural Killer cells. These cells can then activate anti-tumor T cells. Therapies that enhance this pathway may induce sustained anti-tumor effects.

Funding Amount $AUD 488,478.94

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant