Nfib regulates glial differentiation during development and disease via repression of the key epigenetic protein, Ezh2 [ 2012 - 2014 ]

Research Grant

Researchers: A/Pr Michael Piper (Principal investigator) ,  Dr Timothy Bailey ,  E/Pr Andrew Boyd ,  Prof Linda Richards

Brief description Glial development is critical during development, and unrestrained proliferation of glial stem cells in the adult can lead to deadly brain cancers such as glioma. At present there is no cure for glioma and current treatments do not significantly delay tumour progression. Nfib is a transcription factor that may prevent tumour growth through cellular differentiation. We will investigate the role of Nfib during development and in the pathogenesis of glioma and its potential as a therapeutic target.

Funding Amount $AUD 572,912.09

Funding Scheme Project Grants

Notes Standard Project Grant