A new paradigm in redox-mediated cardiac fibrosis [ 2017 - ]

Research Grant

Researchers: Prof Gemma Figtree (Principal investigator) ,  Dr Carmine Gentile ,  Dr Eddy Kizana ,  Prof Burns Blaxall ,  Prof Christopher Hayward
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Brief description Fibrosis is a common feature of many forms of heart disease. Despite the recognised central role of reactive oxygen species (ROS) in cardiac fibrosis, antioxidant approaches have failed in clinical trials. We have discovered a new mechanism for ROS-mediated fibrosis that is depleted in human heart failure, and will test an innovative therapeutic approach that is imminently translatable given the development by members of our team of a specific peptide blocker effective in blocking this pathway.

Funding Amount $867,514.00

Funding Scheme Project Grants

Notes Standard Project Grant