New molecular mechanisms of islet protection against diabetes [ 2018 - ]

Research Grant

Researchers: A/Pr David Laybutt (Principal investigator)

Brief description Type 2 diabetes is an enormous health and economic burden. The mechanisms of β-cell compensation for insulin resistance and of β-cell failure in type 2 diabetes are unclear. This proposal will test the novel hypothesis that the adaptation of endoplasmic reticulum (ER) capacity mediates β-cell compensation, and that the failure of β-cell adaptation to ER stress causes diabetes. The studies will show that targeting ER capacity is an important novel strategy for type 2 diabetes therapy.

Funding Amount $673,259.00

Funding Scheme Project Grants

Notes Standard Project Grant