Research Grant
[Cite as https://purl.org/au-research/grants/nhmrc/1144206]Researchers: A/Pr David Laybutt (Principal investigator)
Brief description Type 2 diabetes is an enormous health and economic burden. The mechanisms of ?-cell compensation for insulin resistance and of ?-cell failure in type 2 diabetes are unclear. This proposal will test the novel hypothesis that the adaptation of endoplasmic reticulum (ER) capacity mediates ?-cell compensation, and that the failure of ?-cell adaptation to ER stress causes diabetes. The studies will show that targeting ER capacity is an important novel strategy for type 2 diabetes therapy.
Funding Amount $AUD 682,684.84
Funding Scheme Project Grants
Notes Standard Project Grant
- nhmrc : 1144206
- PURL : https://purl.org/au-research/grants/nhmrc/1144206
