A new model of asthenospermia and a candidate gene for multiple ciliopathies [ 2010 - 2012 ]

Also known as: A novel cause of cilia dysfunction

Research Grant

[Cite as]

Researchers: Prof Moira O'Bryan (Principal investigator) ,  Dr Tomomoto Ishikawa

Brief description Though the analysis of a unique mouse strain (Mot1) we have identified a previously unknown cause of male infertility and lung disease. We hypothesis that the Mot1 line is a model of human primary cilia dyskinesia and that the Mot1 protein is involved in cilia function. Within this project we will define the consequences of a loss of Mot1 protein function, we will define its binding partners and we will screen for mutations in the corresponding human gene.

Funding Amount $AUD 629,039.19

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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