[Cite as http://purl.org/au-research/grants/nhmrc/606445]
Prof Moira O'Bryan
Dr Tomomoto Ishikawa
Brief description Though the analysis of a unique mouse strain (Mot1) we have identified a previously unknown cause of male infertility and lung disease. We hypothesis that the Mot1 line is a model of human primary cilia dyskinesia and that the Mot1 protein is involved in cilia function. Within this project we will define the consequences of a loss of Mot1 protein function, we will define its binding partners and we will screen for mutations in the corresponding human gene.
Funding Amount $AUD 629,039.19
Funding Scheme NHMRC Project Grants
Standard Project Grant