grant

New mechanisms regulating S100 protein function in inflammation [ 2010 - 2014 ]

Also known as: How S100A12 activates mast cells

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/630647]

Researchers: E/Pr Carolyn Geczy (Principal investigator) ,  A/Pr Nicodemus Tedla Dr Kenneth Hsu

Brief description This project will examine new ways which affect the major effector cells in allergic inflammation and asthma regulated by novel S100 protein mediators. We find a natural protein (S100A12) of the innate immune system, in cells in the lungs of patients with acute asthma. S100A12 activates mast cells to release mediators that trigger asthma attack. We will characterise the proteins with which this protein binds on the cell surface and and determine how this mediates their activation.

Funding Amount $AUD 813,929.92

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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