Research Grant
[Cite as https://purl.org/au-research/grants/nhmrc/442952]Researchers: Prof Andreas Suhrbier (Principal investigator) , Dr Grant Darnell
Brief description Plasminogen activator inhibitor type 2 (PAI-2) or SerpinB2 is a protein that has been extensively studied in the field of cancer prognosis and inflammation. Although it is widely believed that this protein exists outside the cell and inhibits enzymes involved in blood clotting and cell migration, it is becoming increasingly clear that this may not be its primary function. We have identified two important new functions for this protein that are related to activities within the cell. These activities involve regulation of cellular growth and resistence to viral infections. This grant seeks to characterise these different activities and determine how they affect cell behaviour and thereby determine the real role of this protein. Understanding what this protein actually does will have implications for understanding cancer prognosis and antiviral resistance.
Funding Amount $AUD 513,946.74
Funding Scheme NHMRC Project Grants
Notes Standard Project Grant
- nhmrc : 442952
- PURL : https://purl.org/au-research/grants/nhmrc/442952
