A new host-pathogen interaction in arthritis [ 2016 - 2019 ]

Research Grant

Researchers: Prof John Hamilton (Principal investigator) ,  A/Pr Andrew Cook ,  Prof Stuart Dashper

Brief description This proposal aims to examine how the oral bacterial pathogen, P.gingivalis, interacts with the host to worsen the severity of disease in rheumatoid arthritis. We propose a new mechanism whereby the pathogen directly activates a major destructive host pathway to promote tissue and bone destruction, which are two of the clinical hallmarks of rheumatoid arthritis. We also propose that this host-pathogen interaction occurs in periodontal disease.

Funding Amount $AUD 618,998.75

Funding Scheme Project Grants

Notes Standard Project Grant