A new function for histone variants in the tissue-specific regulation of pre-mRNA splicing [ 2014 - 2017 ]

Research Grant

Researchers: Prof David Tremethick (Principal investigator)

Brief description It is estimated that greater than 90% of human genes undergo alternative RNA splicing, which can explain how protein diversity is achieved with a limited number of genes. However, how alternative splicing patterns are established remains poorly understood but is an important question given that 15-50% of human disease mutations are associated with changes to the splicing patterns of RNA. We have uncovered a new splicing mechanism, which involves changing the way DNA is packaged in a cell.

Funding Amount $AUD 657,224.65

Funding Scheme Project Grants

Notes Standard Project Grant