grant

A new function for an old enzyme: Src Protein Kinase directs excitotoxic neuronal death in stroke [ 2013 - 2016 ]

Also known as: How does Src protein kinase cause nerve cell death in stroke?

Funded by National Health and Medical Research Council
Managed by The University of Melbourne
Managed by University of Melbourne
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1050486]

Researchers: A/Pr Heung-Chin Cheng (Principal investigator) ,  Dr Dominic Ng

Brief description In our previous investigation of how brain cells die in patients suffering from stroke, we found that stroke causes aberrant activation of an enzyme called Src in the affected brain cells. Furthermore, this aberrantly activated Src directs the brain cells to undergo cell death. Our proposal, which aims to decipher this neurotoxic mechanism of the aberrantly activated Src will benefit development of new therapeutic strategies to reduce brain damage in stroke patients.

Funding Amount $AUD 513,975.00

Funding Scheme Project Grants

Notes Standard Project Grant

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Subjects
Biochemistry and Cell Biology | Biological Sciences | Cell Neurochemistry | Src-family tyrosine kinases | cell death | cell survival | excitotoxicity | neuronal death | neuronal injury | neuroprotection | phospholipids | protein kinases | stroke |
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