New cardiac ryanodine receptor inhibitors for the treatment of heart failure [ 2011 - 2014 ]

Research Grant

Researchers: Prof Philip Board (Principal investigator) ,  A/Pr Marco Casarotto ,  E/Pr Angela Dulhunty ,  Prof Leonard Arnolda ,  The Australian National University (Managed by)

Brief description We have discovered that a protein that is recognized for its role in phase II detoxification can also modify the calcium signaling that underlies heart function. The small part of the protein that is active in heart tissue differs from the enzyme center that supports detoxification and can thus be used as a therapeutic agent in heart failure and in genetic cardiac conditions. The project is to develop the cardio-active part of the protein for maximum efficacy and for eventual clinical use.

Funding Amount $AUD 612,885.92

Funding Scheme Project Grants

Notes Standard Project Grant