New CaMKII therapeutic targets in Heart Failure with preserved Ejection Fraction [ 2017 - ]

Research Grant

Researchers: Prof Leanne Delbridge (Principal investigator) ,  Dr James Bell ,  Dr Jeff Erickson ,  Prof Jonathan Kalman ,  Prof Stephen Harrap

Brief description Deaths associated with impaired heart muscle relaxation and unstable cardiac cycle rhythm are increasing. The mechanisms by which these pathologies occur are not understood and clinical therapies are lacking. We have novel evidence to suggest that a key signalling protein, CaMKII, is critically involved in the development of these forms of heart pathology. This goal of this project is to identify how CaMKII is implicated in heart failure and dysrhythmia as a basis for designing new therapies.

Funding Amount $740,335.00

Funding Scheme Project Grants

Notes Standard Project Grant