grant

A new BTB-ZF family transcription factor required in development and dysregulated in malignant disease [ 2010 - 2013 ]

Also known as: A new gene that is essential for white blood cell development and dysregulated in cancer

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/637395]

Researchers: Prof Graham Lieschke (Principal investigator)

Brief description We are studying the function and biology of a novel gene that looks like a generegulator. We generated a zebrafish mutant with defective myeloid development, and we found this gene causes the defect. This mutant fish provides a handle on the biological function of the gene in development. This gene has the hallmarks of a transcription factor and we will study how it regulates other genes, and how it may be a target for treatment of several cancers in which expression of this gene is activated.

Funding Amount $AUD 439,813.69

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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