New approaches to target plaque inflammation in atherosclerosis [ 2019 - ]

Also known as: 5019180

Research Grant

[Cite as]

Researchers: Dr Peter Psaltis (Principal investigator)

Brief description Atherosclerosis is the build-up of cholesterol plaques inside blood vessels that cause heart attacks. Macrophages are a type of cell that accumulate inside these plaques to make them grow. I am studying two different approaches to stop this build-up of cholesterol-rich macrophages in plaque to prevent heart attacks. One is the use of an anti-inflammatory, anti-gout drug called colchicine, and the other is to block a molecule called eukaryotic elongation factor 2 kinase (eEF2K).

Funding Amount $386,724.00

Funding Scheme Career Development Fellowships

Notes Clinical CDF

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