Neurodevelopmental outcome after sevoflurane versus dexmedetomidine/remifentanil anaesthesia in infancy: a randomised controlled trial [ 2017 - 2021 ]

Research Grant

Researchers: Prof Andrew Davidson (Principal investigator) ,  A/Pr Katherine Lee ,  Dr Louise Crowe ,  Dr Robyn Stargatt ,  Prof Britta Regli-Von Ungern-Sternberg
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Brief description Evidence in animals show that some anaesthetics affect the developing brain. Some human data also show a link between childhood surgery and poorer neurodevelopmental outcome. It is unknown if this association is due to the anaesthetic. Our recent GAS trial showed no evidence for toxicity after 1 hour of anaesthesic but many children have longer anaesthetics. We plan to enrol 420 infants in a study comparing neurodevelopmental outcome after 2 different anaesthetics for surgery lasting >2 hours.

Funding Amount $AUD 846,446.30

Funding Scheme Project Grants

Notes Standard Project Grant