Neurodegeneration in the ageing brain: how the pathways leading to aggregated protein cause disease [ 2006 - 2010 ]

Research Grant

Researchers: Prof Colin Masters (Principal investigator) ,  A/Pr Anthony White ,  A/Pr Kevin Barnham ,  A/Pr Robert Cherny ,  Prof Andrew Hill
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Brief description The team consists of eight highly experienced research scientists who are dedicated to solving the question of how the brain degenerates in the elderly when associated with the accumulation of certain proteins: e.g. A_ amyloid (Alzheimer�s disease) and PrP (Creutzfeldt-Jakob disease). Understanding the molecular pathways leading to the degeneration (loss of neuronal synapses) will permit the development of rational diagnostic and therapeutic interventions. Over the past five years the program has identified several diagnostic and therapeutic avenues which are now being developed by the Pharmaceutical and Biotechnology industries. Much more research is still required for maximizing the chances of success using these approaches.

Funding Amount $AUD 12,322,837.57

Funding Scheme Programs

Notes Program Grant