Neurobiological Effects of Sleep Apnea and Sleepiness [ 2003 - 2005 ]

Research Grant

Researchers: Prof Ronald Grunstein (Principal investigator) ,  Dr Evian Gordon ,  Prof Caroline Rae ,  Prof Peter Robinson

Brief description Sleep apnea affects over one million Australians. It not only affects the quality of a persons sleep and the oxygen supply to their brain, but can cause sleepiness during the day which can in turn affect the ability of the person to conduct their normal activities. Over 30,000 sleep studies are conducted annually in Australia and current therapies result in significant improvements in the quality of life of the patient. However, the data analysis during these studies does not give a clear indication of the degree to which individual patients may have problems with performing their normal tasks during the day. Tasks like driving vehicles are of particular interest due to the potential for accidents through fatigue or a lack of concentration. This research is designed to investigate the impact of sleep apnea on brain function and daytime performance using certain new techniques - more sophisticated analysis of the brain's activity, detection of brain chemicals and metabolism using a specific form of brain scan called MR spectroscopy, a special monotonous computer based driving simulator, an other tests of performance. We will assess a large group of patients with sleep apnea to determine how the impact of sleep apnea on performance may be differ throughout the population and how this may be affected by the current standard treatment for sleep apnea. We will examine the impact on brain function and performance of removing the current standard therapy in a group of patients previously diagnosed with sleep apnea (as this is a common occurrence in the community). We will also repeat some specific measurements on a control group without any symptoms of sleep apnea for the purpose of comparison. We plan to show a relationship between the effects of sleep apnea and the ability of a person to carry out activities such as driving and thinking. We will then be able to better assess the risk a patient may face and the most appropriate way to treat them.

Funding Amount $AUD 320,437.50

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant