Research Grant
[Cite as https://purl.org/au-research/grants/nhmrc/208961]Researchers: Prof Daine Alcorn (Principal investigator)
Brief description Renal dysplasia and renal cystic disease remain significant clinical problems in the paediatric population. Initial animal experiments have demonstrated that inhibiting the renal vasoactive peptide angiotensin during development results in a form of medullary cystic disease. The experiments in this project are aimed at understanding the specific roles and interactions that angiotensin plays in renal development, particularly in development of the distal nephron, the vasculature and the renal pelvis. Importantly the time course of growth and differentiation of these structures varies and the time course of inactivation of angiotensin may result in different malformations. Information from these studies will allow us to understand how clinical problems can arise when angiotensin is absent or other players modify its action. Such situations can arise in humans through sporadic genetic mutations that may well not manifest in widespread clinical abnormalities.
Funding Amount $AUD 210,990.00
Funding Scheme NHMRC Project Grants
Notes Standard Project Grant
- nhmrc : 208961
- PURL : https://purl.org/au-research/grants/nhmrc/208961
