Research Grant
[Cite as https://purl.org/au-research/grants/nhmrc/491055]Researchers: Prof David Jans (Principal investigator) , Prof Gerard Zambetti
Brief description Trafficking of proteins into the nucleus is critical to mammalian cell function, relating strongly to developmental processes and cancer. We have identified a new class of molecule - negative regulators of nuclear import - that function to prevent entry into the nucleus of key regulators of the cell cycle-apoptosis, and have a potential link thereby to cancer. We propose to determine their mechanism of action, modulation by cellular signals, and how important this is to cell function-cancer.
Funding Amount $AUD 495,829.81
Funding Scheme NHMRC Project Grants
Notes Standard Project Grant
- nhmrc : 491055
- PURL : https://purl.org/au-research/grants/nhmrc/491055
