Narcolepsy with cataplexy: a brain orexin replacement strategy [ 1/1/2021 - 12/31/2023 ]

Research Grant

Brief description Narcolepsy with cataplexy is a debilitating, life-long sleep-wake disorder, caused by the irreversible loss of the brain peptide 'orexin'. There is no satisfactory and safe treatment. We aim to develop an orexin analogue, delivered directly to the brain of sheep (relevant in size and translatable to patients) by a programmable pump to timely activate the orexin 'wake-up' switch. This innovative precision medicine project will significantly improve the quality of life of narcolepsy patients.

Funding Amount $810,784

Funding Scheme Ideas Grants

Chief Investigator Prof Daniel Hoyer

Notes Ideas Grants