NAD+ and SIRT2 regulation of mitotic lifespan, senescence and healthy ageing [ 2014 - 2017 ]

Research Grant

Researchers: A/Pr Nigel Turner (Principal investigator) ,  Prof David Le Couteur ,  Prof David Sinclair

Brief description During youth, cells in our body undergo a continual process of self-renewal, known as mitosis, where cells divide and accurately provide equal number of chromosomes into each daughter cell. During old age, dysfunctional mitosis leads to senescence, where cells no longer divide, and are unable to renew old tissue. We have uncovered a new molecular pathway involving the enzyme SIRT2 that maintains healthy mitosis, and will determine if targeting this pathway preserves health into old age, and ultimately extends lifespan

Funding Amount $AUD 617,274.01

Funding Scheme Project Grants

Notes Standard Project Grant