Myelin lipid breakdown affected by Apolipoprotein E genotype: implications for Alzheimer’s Disease pathogenesis [ 2016 - 2020 ]

Research Grant

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Brief description This project pieces together two important questions about Alzheimer’s Disease: (1) Why a naturally occurring variant of a gene called “APOE“ is the primary genetic risk for Alzheimer’s. (2) Why Alzheimer’s preferentially affects brain regions that lose a fatty substance called myelin, the electrical insulation of the brain. In doing so, we will understand more about what makes people more susceptible to Alzheimer’s and whether therapies to restore myelin could be effective against Alzheimer’s.

Funding Amount $AUD 549,686.75

Funding Scheme Targeted Calls

Notes NHMRC-ARC Dementia Research Development Fellowship

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