Mucins in Gastrointestinal Barrier Function [ 2006 - 2008 ]

Research Grant

Researchers: Prof Michael Mcguckin (Principal investigator) ,  Dr Sara Linden ,  Prof Philip Sutton ,  Prof Timothy Florin ,  Prof Victoria Korolik

Brief description Epithelial cell surface mucins are large complex proteins found on the surface of all mucosal epithelial tissues, for example in the respiratory, gastrointestinal, reproductive and urinary tracts. Most bacterial and viral pathogens enter the body via mucosal tissues. We have recently demonstrated that mucin proteins are a vital component of initial defence against mucosal pathogens. Defects in these proteins probably predispose individuals to common chronic infective and inflammatory diseases. The proposed research aims to explore the mechanims by which mucins protect from infection, with a focus on the gastrointestinal tract. Gastrointestinal infections remain one of the major causes of mortality in children in undeveloped countries. We believe that these proteins are a critical hereto unrecognised element of immunity and that the proposed studies will have broad significance for treatment and prevention of infection. Additionally, understanding the function of mucins could lead to the development of new drugs to treat epithelial inflammation such as that seen in inflammatory bowel diseases and respiratory diseases such as asthma and cystic fibrosis.

Funding Amount $AUD 523,523.48

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant