MOZ regulates cellular senescence [ 2015 - 2017 ]

Research Grant

Researchers: A/Pr Tim Thomas (Principal investigator) ,  A/Pr Anne Voss

Brief description We have recently discovered that MOZ (monocytic leukaemia zinc finger gene), a gene first identified in rmutations leading to a particularly aggressive form of leukaemia, is a major regulator of senescence. In the absence of MOZ cells exit the cell cycle and become senescent, independently of DNA damage. These obsevations are very important for understanding cancer development because for cancer to grow and spread the cells must avoid senescence.

Funding Amount $AUD 498,432.04

Funding Scheme Project Grants

Notes Standard Project Grant