grant

Molecular Regulation of tumourigenesis by the polarity determinant Scribble and associated proteins [ 2011 - 2013 ]

Also known as: How does Tissue Architecture control Cancer?

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1004434]

Researchers: Prof Patrick Humbert (Principal investigator)

Brief description Cell polarity is the property of cells to be spatially oriented in a tissue or organ. We have shown that Scribble, a key regulator of cell orientation, may keep tumour development in check. In this proposal, we will examine how disruption of Scribble promotes breast cancer using a combination of tissue culture studies and a newly established mouse model. Understanding how this new pathway can regulate breast tumour development may provide novel targets for therapeutic intervention in cancer.

Funding Amount $AUD 614,421.29

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Identifiers
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ACN 633 798 857