Molecular pathogenesis of herpes simplex virus latency and reactivation : relationship with viral genomic structure [ 2000 - 2002 ]

Research Grant

Researchers: A/Pr Peter Speck (Principal investigator) ,  Dr Anthony Simmons (Principal investigator) ,  E/Pr Christopher Burrell

Brief description A major target for antiviral drugs that combat herpes simplex infections, such as genital herpes and herpes encephalitis, is replication of viral DNA. There are significant gaps in the understanding of herpes simplex virus DNA replication which are addressed in this project. Further, a major factor responsible for the high impact of herpes simplex on the community is virus' ability to lie dormant (latent) in the body. The significance of lateny is that it periodically reactivates giving rise to recurrent infections. In molecular terms, latency is a reversible interruption of viral DNA replication, but the precise mechanisms involved are incompletely understood. This project explores ways in which latency might be established and reactivated. This information may eventually lead to improved strategies for reducing the burdens caused by herpes simplex virus infections.

Funding Amount $AUD 217,060.39

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant