grant

Molecular mechanisms mediating experience-dependent cellular plasticity and cognitive deficits in Huntingtons disease [ 2008 - 2010 ]

Also known as: The molecular and cellular basis of dementia in Huntingtons disease

Funded by National Health and Medical Research Council
Managed by The University of Melbourne
Managed by University of Melbourne
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/509031]

Researchers: Prof Anthony Hannan (Principal investigator)

Brief description We will use a genetic mouse model of Huntington's disease (HD), to understand how cognitive disorders (dementia) are caused, focusing on cells and molecules within the brain. We will investigate how the HD gene mutation disrupts communication between brain cells (neurons), as well as disrupting production of new cells (via adult neural stem cells). The results of this project will not only have implications for treating HD but also for other diseases involving dementia, such as Alzheimer's.

Funding Amount $AUD 550,387.18

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Related Publications

  • Associated with Impaired basal and running-induced hippocampal neurogenesis coincides with reduced Akt signaling in adult R6/1 HD mice
    handle : 11343/44170
  • Associated with Impaired basal and running-induced hippocampal neurogenesis coincides with reduced Akt signaling in adult R6/1 HD mice
    handle : 11343/41924

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Related People

Subjects
Biomedical and Clinical Sciences | Huntington's disease | Medical Infection Agents (Incl. Prions) | Medical Microbiology | adult neurogenesis | cognitive disorders | dementia | gene-environment interactions | molecular neuroscience | neurodegeneration | neurodegenerative diseases | synaptic plasticity | trinucleotide repeat expansion brain disorders |
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ACN 633 798 857