Molecular mechanisms of dynamin-mediated endocytosis in nerve terminals [ 2014 - 2017 ]

Research Grant

Researchers: Prof Phillip Robinson (Principal investigator)

Brief description Neurons communicate by neurotransmitter release from synaptic vesicles stored in nerve endings. There is a finite vesicle number, so they are recycled (endocytosis) by the protein dynamin. Our aim is to reveal how new vesicles are produced when the brain is under very high activity, to better understand diseases of the synapse like epilepsy. We propose that two forms of the dynamin gene mediate this process, only under conditions of high neuronal firing, such as occurs during a seizure.

Funding Amount $AUD 992,296.00

Funding Scheme Project Grants

Notes Standard Project Grant