What is the molecular mechanism underlying cell death by necroptosis? [ 2017 - 2019 ]

Research Grant

Researchers: A/Pr James Murphy (Principal investigator) ,  A/Pr Peter Czabotar ,  Dr Andrew Webb

Brief description Recently, we and others have demonstrated that part of the MLKL protein is able to kill cells. This process is known to cause a number of pathologies, including those arising from stroke. Blocking this type of cell death has thus emerged as an attractive therapeutic strategy. However, precisely how MLKL kills cells remains unclear and controversial. In this project, we will resolve these controversies with the goal of an increased fundamental understanding to aid drug discovery.

Funding Amount $AUD 668,939.46

Funding Scheme Project Grants

Notes Standard Project Grant