Molecular machines: regulation of the catalysis and rotation of the enzyme ATP synthase [ 2003 - 2005 ]

Research Grant

Researchers A/Prof MC Wilce Prof Dr RA Capaldi Prof K Schulten

Brief description This project aims to elucidate the regulation of the molecular machine ATP synthase. ATP synthase is an enzyme that performs a critical role in all cells - the synthesis of ATP, the universal biological energy currency. It is known that the enzyme operates via rotation of a central stalk which is driven by a hydrogen ion gradient across a membrane. Constructs of this molecule have been envisaged in the design of future biological nano-motors. Our work will provide an understanding of the regulation of this enzyme with potential application in the control of nano-motors.

Funding Amount $310,000

Funding Scheme Discovery Projects