Molecular interactions of novel conotoxin inhibitors of the noradrenaline transporter [ 2001 - 2003 ]

Research Grant

Researchers: Prof Richard Lewis (Principal investigator) ,  Prof David Adams ,  Prof Paul Alewood

Brief description A novel class of conotoxins (chi-conotoxins) has been discovered in the venom of an Australian cone snails, Conus marmoreus. Chi-conotoxins are the first peptide inhibitors of the noradrenaline transporter. From binding studies, it appears they act at a new site, remote from the site of action of antidepressants. This project is aimed at understanding how and where this novel class of peptide binds to the transporter. The results of this study are designed to maximise the potential of these patented peptides to be used as leads to the development of a new class of therapeutic for controlling the adverse effects of inadequate noradrenaline balance.

Funding Amount $AUD 392,036.72

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant