Molecular genetics of the host response defect in cystic fibrosis [ 2007 - 2008 ]

Research Grant

Researchers: Prof Brandon Wainwright (Principal investigator) ,  Prof David Hume

Brief description Cystic fibrosis is the most common lethal genetic disease in Caucasian populations. Affected individuals suffer from a number of symptoms but the most serious is a chronic infect with the bacterial pathogen Pseudomonas aeruginosa. The sustained lung inflammation caused by infection with Pseudomonas aeruginosa ultimately destroys the structure of the lung to the point where it can no longer function. Gene therapy has been suggested as a possible treatment for the disease but another approach is to identify the CF specific aspects of the inflammatory response and target those for therapeutic development. In our previous work we have identified several strong candidates for the inflammatory molecules in the CF lung and in this application we will test those candidates to see whether they play a major role in CF lung disease.

Funding Amount $AUD 564,690.64

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant