Molecular genetics of cystic fibrosis [ 2003 - 2005 ]

Research Grant

Researchers: Prof Brandon Wainwright (Principal investigator) ,  Prof David Hume

Brief description Cystic fibrosis is a life-threatening disease of the lungs and digestive system. It is the most common single gene disorder of Caucasian populations and most of the moratility is caused by the presence of chronic lung infections, most notably with the bacterial pathogen, Pseudomonas aeruginosa. Despite the cystic fibrosis gene being discovered over 10 years ago we still have no clear indication as to how defects in the CF gene cause susceptibility to bacterial infections, and result in the inflammation of the lung. Our studies address this issue by examining thechanges of gene expression in response to infection with Pseudomonas aeruginosa and therefore provide us with routes to therapies which are targetted against CF gene mediated inflammation.

Funding Amount $AUD 598,125.00

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant