Research Grant
[Cite as https://purl.org/au-research/grants/nhmrc/275545]Researchers: E/Pr Peter Mackenzie (Principal investigator)
Brief description The gastrointestinal tract is a major portal of entry for dietary chemicals and drugs taken orally or as suppositories. Enzymes resident in the gastrointestinal tract have an essential role in preventing these chemicals from reaching other organs and target tissues in the body and in protecting the gastrointestinal tract per se from their effects. The levels of these enzymes in the gastrointestinal tract varies quite extensively between individuals. In this project we will determine how these enzymes are regulated and what causes the large differences in their levels between individuals. This will help us to predict those individuals who are more at risk from the adverse effects of drugs taken orally or as suppositories and from the toxic effects of chemicals in the diet. The project will also help us identify therapies that can increase the levels of these protective enzymes to help reduce the effects of exposure to toxic chemicals .
Funding Amount $AUD 447,750.00
Funding Scheme NHMRC Project Grants
Notes Standard Project Grant
- nhmrc : 275545
- PURL : https://purl.org/au-research/grants/nhmrc/275545
